研究
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原口健

職種 特任准教授
所属プロジェクト ＲＮＡ制御プロジェクト
研究部門 真菌症研究部門
分野 ＲＮＡ感染治療学分野
TEL 043-226-2801
FAX
E-mail haraguti[at]chiba-u.jp
プロフィール写真

専門分野

microRNA、がん

研究テーマ

microRNAを標的としたがん治療法の開発

所属学協会

日本ウイルス学会、日本分子生物学会、日本癌学会

主な発表論文、著書

    Researchmap

    1. Kobayashi K*, Hiramatsu H*, Nakamura S, Kobayashi K, Haraguchi T, Iba H. (* equally contributed) Tumor suppression via inhibition of SWI/SNF complex-dependent NF-κB activation. Scientific Reports, 7:11772 (2017)
    2. Kobayashi K, Suemasa F, Sagara H, Nakamura S, Ino Y, Kobayashi K, Hiramatsu H, Haraguchi T, Kurokawa K, Todo T, Nakano A, Iba H. MiR-199a inhibits secondary envelopment of Herpes Simplex Virus-1through the downregulation of Cdc42-specific GTPase activating protein localized in Golgi apparatus. Scientific Reports, 7:6650 (2017)
    3. Hiramatsu H, Kobayashi K, Kobayashi K, Haraguchi T, Ino Y, Todo T, Iba H. The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells. Scientific Reports, 7:889 (2017)
    4. Haraguchi T, Kondo M, Uchikawa R, Kobayashi K, Hiramatsu H, Kobayashi K, Chit UW, Shimizu T, Iba H. Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition. Scientific Reports 6:21117 (2016)
    5. Kobayashi K, Sakurai K, Hiramatsu H, Inada K, Shiogama K, Nakamura S, Suemasa F, Kobayashi K, Imoto S, Haraguchi T, Ito H, Ishizaka A, Tsutsumi Y, Iba H. The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Scientific Reports 5:8428 (2015)
    6. Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun 3:1034 (2012)
    7. Tagawa T, Haraguchi T, Hiramatsu H, Kobayashi K, Sakurai K, Inada K, Iba H. Multiple microRNAs induced by Cdx1 suppress Cdx2 in human colorectal tumor cells. The Biochem J. 447(3):449-55. (2012)
    8. Haraguchi T, Nakano H, Tagawa T, Ohki T, Ueno Y, Yoshida T, Iba H. A potent 2’-O-methylated RNA-based microRNA inhibitor with unique secondary structures. Nucleic Acids Res. 40(8):e58 (2012)
    9. Hikichi M, Kidokoro M, Haraguchi T, Iba H, Shida H, Tahara H, Nakamura T. MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy. Mol Ther. 19(6):1107-15. (2011)
    10. Sakurai K, Furukawa C, Haraguchi T, Inada K, Shiogama K, Tagawa T, Fujita S, Ueno Y, Ogata A, Ito M, Tsutsumi Y, Iba H. MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 71(5):1680-9. (2011)
    11. Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H. Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. J Biol Chem. 16;285(29):21951-60. (2010)
    12. Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, Fujita S, Mizutani T, Furukawa C, Fujishiro M, Ichinose M, Shiogama K, Tsutsumi Y, Omata M, Iba H. Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development. Clin Cancer Res. 15(12):4009-16 (2009)
    13. Haraguchi T, Ozaki Y, Iba H. Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res. 37(6):e43 (2009)
    14. Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H. Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells. Exp. Cell Res. 315(10):1779-89 (2009)
    15. Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi T, Mizutani T, Sakurai K, Fujita S, Izumi T, Isobe T, Iba H. Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb). Biochem J. 411, 201-209 (2008).
    16. Yamamichi N, Inada K, Ichinose M, Yamamichi-Nishina M, Mizutani T, Watanabe H, Shiogama K, Fujishiro M, Okazaki T, Yahagi N, Haraguchi T, Fujita S, Tsutsumi Y, Omata M, Iba H. Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. Cancer Res. 67,10727-10735 (2007).
    17. Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, Iba H. SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells. FEBS Lett. 581, 4949-4954 (2007).
    18. Watanabe H, Mizutani T, Haraguchi T, Yamamichi N, Minoguchi S, Yamamichi-Nishina M, Mori N, Kameda T, Sugiyama T, Iba H. SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines. Oncogene, 25, 470?479 (2006).
    19. Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. 32, 936-948 (2004).