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Akira Watanabe

Position Professor
Research Projects Project to Link Basic Sciences and Clinical Medicine
Division Division of Clinical Research
TEL +81 43 226 2786
FAX
E-mail fewata[at]faculty.chiba-u.jp
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Specialities

Infectious diseases, fungal infection, mycology, respirology

Main topics of research

Fungal infection, antifungal resistance of pathogenic fungi

Main publications

  1. Van Braeckel E, Page I, Davidsen J, Laursen C, Agarwal R, Alastruey-Izquierdo A, Barac A, Cadranel J, Chakrabarti A, Cornely O, Denning D, Flick H, Gangneux JP, Godet C, Hayashi Y, Hennequin C, Hoenigl M, Irfan M, Izumikawa K, Koh WJ, Kosmidis C. Lange C, Lamprecht B, Laurent F, Munteanu O, Oladele R, Patterson T, Watanabe A, Salzer H: Treatment outcome definitions in chronic pulmonary aspergillosis: a CPAnet consensus statement. Eur Respir J 59(6): 2102950, 2022
  2. Takamatsu A, Yaguchi T, Tagashira Y, Watanabe A, Honda H: Nocardiosis in Japan: a multicentric retrospective cohort study. Antimicrob Agents Chemother 66(2): e01890-21, 2022.
  3. Takeda K, Suzuki J, Watanabe A, Narumoto O, Kawashima M, Sasaki Y, Nagai H, kamei K, Matsui H: Non-fumigatus Aspergillus infection associated with a negative Aspergillus precipitin test in patients with chronic pulmonary aspergillosis. J Clin Microbiol 60(2): e0201821, 2022.
  4. Khalifa HO, Hubka V, Watanabe A, Nagi M, Miyazaki Y, Yaguchi T, Kamei K: Prevalence of Antifungal Resistance, Genetic Basis of Acquired Azole and Echinocandin Resistance, and Genotyping of Candid krusei recovered from an International Collection. Antimicrob Agents Chemother 66(2): e0185621, 2022.
  5. Takeda K, Suzuki J, Watanabe A, Sekiguchi R, Sano T, Narumoto O, Kawashima M, Fukami T, Sasaki Y, Tamura A, Nagai H, Matsui H, Kamei K: The accuracy and clinical impact of the morphological identification of Aspergillus species in the age of cryptic species: A single-centre study. Mycoses 65(2):164-170, 2022.
  6. Khalifa HO, Watanabe A, Kamei K: Azole and Echinocandin Resistance Mechanisms and Genotyping of Candida tropicalis in Japan: Cross-Boundary Dissemination and Animal-Human Transmission of C. tropicalis Infection. Clin Microbiol Infect 28(2): 302.e5-302.e8, 2022.
  7. Toh-E A, Ohkusu M, Ishiwada N, Watanabe A, Kamei K: Genetic system underlying responses of Cryptococcus neoformans to cadmium. Curr Genet 68(1): 125-141, 2022.
  8. Majima H, Arai T, Kusuya Y, Takahashi H, Watanabe A, Miyazaki Y, Kamei K: Genetic differences between Japan and other countries in cyp51A polymorphisms of Aspergillus fumigatus. Mycoses 64(11): 1354-1365, 2021.
  9. Arai, T, Umeyama, T, Majima, H, Inukai, T, Watanabe, A, Miyazaki, Y, Kamei, K: Hmg1 mutations in Aspergillus fumigatus and their contribution to triazole susceptibility. Med Mycol 59(10): 980-984, 2021.
  10. Hino Y, Watanabe A, Seki R, Tsukamoto S, Takeda Y, Sakaida E, Kamei K: A Reference Laboratory Surveillance on Fungal Isolates from Patients with Haematological Malignancy in Japan. J Fungi(Basel) 7(10): 806, 2021.
  11. Toyotome T, Onishi K, Sato M, Hagiwara D, Watanabe A, Takahashi H: Identification of novel mutations contributing to azole tolerance of Aspergillus fumigatus through in vitro exposure to tebuconazole. Antimicrob Agents Chemother 65(9): e0265720, 2021.
  12. Trabasso P, Matsuzawa T, Arai T, Hagiwara D, Mikami Y, Moretti ML, Watanabe A: Development and validation of LAMP primer sets for rapid identification of Aspergillus fumigatus carrying the cyp51A TR46 azole resistance gene. Sci Rep 11(1):17087, 2021.
  13. Martins AC, Psaltikidis EM, Lima TC, Fagnani R, Schreiber AZ, Conterno LO, Kamei K, Watanabe A, Trabasso P, Resende MR, Moretti ML: COVID-19 and invasive fungal coinfections: a case series at a Brazilian referral hospital. J Med Mycol 31(4): 101175, 2021.
  14. Takahashi H, Umemura M, Ninomiya A, Kusuya Y, Shimizu M, Urayama S, Watanabe A, Kamei K, Yaguchi T, Hagiwara D: Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes in Aspergillus Section Fumigati. Front Fungal Biol, April 2021.Volume 2, Article 656751.
  15. Zhao S, Ge W, Watanabe A, Fortwende JR, Gibbons JG: Genome-Wide Association for Itraconazole Sensitivity in Non-Resistant Clinical Isolates of Aspergillus fumigatus. Front Fungal Biol, January 2021, Volume 1, Article 617338.
  16. Khalifa HO, Arai T, Majima H, Watanabe A, Kamei K: Evaluation of Surveyor Nuclease for rapid identification of FKS genes mutations in Candida glabrata. J Infect Chemother 27(6): 834-839, 2021
  17. Takeda K, Suzuki J, Watanabe A, Arai, T, Koiwa T, Shinfuku K, Narumoto O, Kawashima M, Fukami T, Tamura A, Nagai H, Matsui H, Kamei K: High detection rate of azole-resistant Aspergillus fumigatus after treatment with azole antifungal drugs among patients with chronic pulmonary aspergillosis in a single hospital setting with low azole resistance. Med Mycol 59(4): 327-334, 2021.
  18. Nguyen PT, Toh-E A, Nguyen NH, Imanishi-Shimizu Y, Watanabe A, Kamei K, Shimizu K: Identification and characterization of a sulfite reductase gene and new insights regarding the sulfur-containing amino acid metabolism in the basidiomycetous yeast Cryptococcus neoformans. Curr Genet 67(1): 115-128, 2021.
  19. Khalifa HO, Majima H, Watanabe A, Kamei K: In Vitro Characterization of Twenty-One Antifungal Combinations against Echinocandin-Resistant and -Susceptible Candida glabrata. J Fungi(Basel) 7(2): 108, 2021.
  20. Izumikawa K, Kakeya H, Sakai F, Shibuya K, Sugita T, Takazono T, Takata T, Tashiro M, Teruya K, Nakamura S, Noguchi H, Hiruma M, Makimura K, Miyazaki T, Miyazaki Y, Yamagishi Y, Yoshida K, Watanabe A: Executive Summary of JSMM Clinical Practice Guidelines for Diagnosis and Treatment of Cryptococcosis 2019. Med Mycol J 61(4): 61-89, 2020.
  21. Khalifa HO, Arai T, Majima H, Watanabe A, Kamei K: Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan. Antimicrob Agents Chemother 64(9): e00783-20, 2020.
  22. Hino Y, Muraosa Y, Oguchi M, Yahiro M, Yarita K, Watanabe A, Sakaida E, Yokote K, Kamei K: Drain outlets in patient rooms as sources for invasive fusariosis: an analysis of patients with haematological disorders. J Hosp Infect 105(3): 518-526, 2020.
  23. Takeda K, Suzuki J, Watanabe A, Matsuki M, Higa K, Inoue E, Akashi S, Shimada M, Kawashima M, Ohshima N, Fukami T, Masuda K, Yamane A, Tamura A, Nagai H, Matsui H, Tohma S, Kamei K: Species identification, antifungal susceptibility, and clinical feature association of Aspergillus section Nigri isolates from the lower respiratory tract. Med Mycol 58(3): 310-314, 2020.
  24. Arai T, Majima H, Watanabe A, Kamei K: A simple method to detect point mutations in Aspergillus fumigatus cyp51A gene using a Surveyor Nuclease assay. Antimicrob Agents Chemother 64(4): pii: e02271-19, 2020.
  25. Pontes L, Beraquet CA, Arai T, Pigolli G, Lyra L, Watanabe A, Moretti ML, Schreiber A: Aspergillus fumigatus clinical isolates carrying CYP51A TR34/L98H/S297T/F495I mutation detected after 4 years retrospective azole resistance screening test in Brazil. Antimicrob Agents Chemother 64(3): pii: e02059-19, 2020.
  26. Toyotome T, Arai T, Watanabe A, Kamei K: Detection of substitutions at 98th, 121st, and 289th amino acid residues in Cyp51A using cycling probes. Med Mycol J 61(1): 7-10, 2020.
  27. Chihara Y, Tanaka Y, Izumi M, Hagiwara D, Watanabe A, Takegawa K, Kamei K, Shibata N, Ohta K, Oka T: Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O-Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus. mSphere 5(1): pii: e00770-19, 2020.

Website

http://clinical-r.pf.chiba-u.jp/