Scientist ＆ Research
Home > Scientist ＆ Research > Scientists > Tohru Gonoi

Tohru Gonoi

Position Professor
Research Projects Project for Host Pathogen (fungi/actinomycetes) Molecular Interaction
Division Division of Bio-resources
TEL +81 43 226 2492
FAX +81 43 226 2486
E-mail gonoi[at]faculty.chiba-u.jp
プロフィール写真

Specialities

In cooperation with Bio-Resource management office, we collect pathogenic fungi and actinomycetes in both inside and outside of Japan. We identify pathogenic fungi and actinomycetes as a public service, and analyze their phylogenetic relations. We store fungi and actinomycetes with the support of the National BioResource Projects in Japan, and distribute them upon request. Currently we stock approximately 20, 000 strains. We analyze sequences of marker genes and genomes, drug-sensitivities, and observe fine structures using electron-microscopy, to enhance biodiversity values. Other projects are listed below.

Main topics of research

  1. We collect, identify and phylogenetically analyze of human and animal pathogenic fungi and actinomycetes. We also analyze 2nd metabolites and their synthetic enzymes, pathogenic factors, and genomes.
  2. We analyze infection mechanisms of human pathogenic fungi and actinomycetes using molecular methods, animal models, and genome analysis. In particular, we are trying to understand roles of cell surface glycans and their receptors (lectins) of human and fungi in infection.
  3. We study effects of diets and mental stresses on fungal infections mainly using animal models and molecular methods. We are trying to clarify yet unknown links between metabolism and immune-related molecules.
  4. Physiological and molecular biological analyses of mycoviruses which infect pathogenic filamentous fungi.

Main publications

  1. Nakamura I, Nagakura T, Fujita H, Fukusima S, Gonoi T. Nocardia elegans infection: a case report and literature review. Int J Infect Dis, in press.
  2. Kuchibiro T, Ikeda T, Nakanishi H, Morishita Y, Houdai K, Ito J, Gonoi T. First case report of pulmonary nocardiosis caused by Nocardia mexicana. JMM Case Reports, in press.
  3. Kubota T, Nakamura K, Sakai K, Fromont J, Gonoi T, Kobayashi J. Hyrtinadines C and D, New Azepinoindole-Type Alkaloids from a Marine Sponge Hyrtios sp. Chem Phar Bull 64: 975-978, 2016.
  4. Langat G, Matsusawa T, Gonoi T, Matiru V, Christine Bii C. Aflatoxin M1 Contamination of milk and its products in Bomet County, Kenya. Adv Microbiol, 6, 528-536, 2016.
  5. Numata S, Numata T, Gonoi T, Matsunaga K. Successful treatment of primary cutaneous Nocardia brasiliensis infection with oral potassium iodide. J Dermatol 43: 843-844, 2016.
  6. Condas LAZ, Ribeiro MG, Muro MD, Vargas APC, Matsuzawa T, Yazawa K, Siqueira AK, Salerno T, Lara GHB, Risseti RM, Spadari K, Gonoi T. Molecular identification and antimicrobial resistance pattern of seven clinical isolates of Nocardia spp in Brazil. REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SÃO PAULO ; 57(3):251-6, 2015.
  7. Condas LAZ, Ribeiro MG, Olivo G, Franco MMJ, Gonoi T, Matsuzawa T, Yazawa K, Goncalves RC, Borges AS. Nocardia nova identification in a transtracheal wash of a horse with recurrent airway obstruction. Archivos de Medicina Veterinaria 47:231-235, 2015.
  8. Kubota T, Iwai T, Ishiyama H, Sakai K, Gonoi T, Kobayashi J. Amphidinin G, a putative biosynthetic precursor of amphidinin A from marine dinoflagellate Amphidinium sp. Tetrahedron lett. 56: 990-3, 2015.
  9. Kubota T, Watase S, Sakai K, Fromont J, Gonoi T, Kobayashi J. Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge. Bioorg Med Chem Lett. pii: S0960-894X(15)30095-0, 2015.
  10. Matsuzawa T, Campos Takaki GM, Yaguchi T, Okada K, Abliz P, Gonoi T, Horie Y. Aspergillus arcoverdensis, a new species of Aspergillus section Fumigati isolated from caatinga soil in State of Pernambuco, Brazil. Mycoscience 56:123-131, 2015.
  11. Nakamura K, Kusama T, Tanaka N, Sakai K, Gonoi T, Fromont J, Kobayashi J. 2-Debromonagelamide U, 2-debromomukanadin G, and 2-debromonagelamide P from marine sponge Agelas sp. Heterocycles 90: 425-31, 2015.
  12. Oarada M, Takahashi-Nakaguchi A, Abe T, Nikawa T, Miki T, Gonoi T. Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice.Nutrition 31:757-65, 2015.
  13. Oya A, Tanaka N, Kusama T, Kim SY, Hayashi S, Kojoma M, Hishida A, Kawahara N, Sakai K, Gonoi T, Kobayashi J. Prenylated Benzophenones from Triadenum japonicum. J Natural Products 78: 258-264, 2015.
  14. Sakai K, Komaki H, Gonoi T. Identification and Functional Analysis of the Nocardithiocin Gene Cluster in Nocardia pseudobrasiliensis. PLoS One ;10(11):e0143264, 2015.
  15. Takahashi-Nakaguchi A, Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H. Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. Med Mycol 53-535-60, 2015.
  16. Tanaka N, Suto S, Asai M, Kusama T, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. Halichonadins M-Q, sesquiterpenes from an okinawan marine sponge Halichondria sp. Heterocycles 90: 173-185, 2015.
  17. Toh-e A, Ohkusu M, Li HM, Shimizu K, Takahashi-Nakaguchi A, Gonoi T, Kawamoto S, Kanesaki Y, Yoshikawa H, Nishizawa M. Identification of genes involved in the phosphate metabolism in Cryptococcus neoformans. Fungal Genet Biol ; 80:19-30, 2015.
  18. Hagiwara D, Suzuki S, Kamei K, Gonoi T, Kawamoto S. The role of AtfA and HOG MAPK pathway in stress tolerance in conidia of Aspergillus fumigatus. Fungal Genetics and Biology 73:138-49, 2014.
  19. Hagiwara D, Takahashi H, Watanabe A, Takahashi-Nakaguchi A, Kawamoto S, Kamei K, Gonoi T. Whole-genome comparison of Aspergillus fumigatus strains serially isolated from patients infected with aspergillosis. J Clin Microbiol ;52(12):4202-9, 2014.
  20. Ishihara M, Takada D, Sugimoto K, Oguro H, Gonoi T, Akiyama Y, Yamaguchi S. Primary brain abscess caused by Nocardia otitidiscaviarum. Intern Med 53(17):2007-2012, 2014.
  21. Kang Y, Ming H, Gonoi T, Chen Y, Cao Y,Wang Y, Cheng J, Koga T, Mikami Y, Li W-J.  Gordonia iterans sp. nov., isolated from a patient with pneumonia. Int J Syst Evol Microbiol 64:3520-5, 2014.
  22. Kirui MC, Alakonya AE, Talam KK, Gonoi T, Bii CC. Total aflatoxin, fumonisin and deoxynivalenol contamination of busaa in Bomet county, Kenya.  African Journal of Biotechnology 13(26): 2675-2678, 2014.
  23. Komaki H, Ichikawa N, Hosoyama A, Takahashi-Nakaguchi A, Matsuzawa T, Suzuki K-I, Fujita N, Gonoi T.  Genome based analysis of type-I polyketide synthase and nonribosomal peptide synthetase gene clusters in seven strains of five representative Nocardia species. BMC genomics 15:323, 2014.
  24. Kubota T, Iwai T, Sakai K, Gonoi T, Kobayashi J. Amphidinins C-F, amphidinolide Q analogues from marine dinoflagellate Amphidinium sp. Org Lett 16:5624-7, 2014.
  25. Kubota T, Suzuki H, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J.  Taurospongins B and C, new acetylenic fatty acid derivatives possessing a taurine amide residue from a marine sponge of the family Spongiidae. RSC Advances 4(22): 11073-11079, 2014.
  26. Kusama T, Tanaka N, Sakai K, Gonoi T, Fromont J, Kashiwada Y, Kobayashi J. Agelamadins A and B, dimeric bromopyrrole alkaloids from a marine sponge Agelas sp. Org Lett 16(15): 3916-3918, 2014.
  27. Kusama T, Tanaka N, Sakai K, Gonoi T, Fromont J, Kashiwada Y, Kobayashi J. Agelamadins C-E, bromopyrrole alkaloids comprising oroidin and 3-hydroxykynurenine from a marine sponge Agelas sp. Org Lett 16:5176-9, 2014.
  28. Kusama T, Tanaka N, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. Bromopyrrole alkaloids from a marine sponge Agelas sp. Chem Pharm Bull (Tokyo) 62(5):499-503, 2014.
  29. Matsuzawa T, Takaki GMC, Yaguchi T, Okada K, Gonoi T, Horie Y. Two new species of Aspergillus section Fumigati isolated from caatinga soil in the State of Pernambuco, Brazil. Mycoscience 55(2):79-88, 2014.
  30. Ooi Y, Shiba H, Nagai K, Higashiyama T, Nakanishi T, Nakano T, Ukimura A, Gonoi, T. Lung Nocardia elegans infection diagnosed on matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) Intern Med 53(18): 2111-2113, 2014.
  31. Rosana Y, Matsuzawa T, Gonoi T, Karuniawati A. Modified slide culture method for faster and easier identification of ermatophytes Microbiology Indonesia 8:1-5 , 2014
  32. Sakai K, Trabasso P, Moretti ML, Mikami Y, Kamei K, Gonoi T. Identification of Fungal Pathogens by Visible Microarray System in Combination with Isothermal Gene Amplification. Mycopathologia  178(1-2): 11–26, 2014.
  33. Shibazaki A, Gonoi T. Lectin-microarray technique for glycomic profiling of fungal cell surfaces. Methods Mol Biol 1200: 287-294, 2014.
  34. de Souza M, Matsuzawa T, Lyra L, Busso-Lopes AF, Gonoi T, Schreiber AZ, Kamei K, Moretti ML, Trabasso P. Fusarium napiforme systemic infection: case report with molecular characterization and antifungal susceptibility tests. SpringerPlus 3: 492, 2014.
  35. Suzuki H, Kubota T, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J. Nakijiquinone S (Ia) and Nakijinol C (Ib), new meroterpenoids from a marine sponge of the family Spongiidae. Chem Pharm Bull (Tokyo) 62(2): 209-212, 2014.
  36. Tanaka N, Momose R, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. Hyrtimomines, indole alkaloids from Okinawan marine sponges Hyrtios spp. Tetrahedron 70:832-837, 2014. 
  37. Tanaka N, Tsuji E, Sakai K, Gonoi T, Kobayashi J. Hikiokoshins A–I, diterpenes from the leaves of Isodon japonicus. Phytochemistry 102: 205-210, 2014.
  38. Wu S, Nakamoto S, Kanda T, Jiang X, Nakamura M, Miyamura T, Shirasawa H, Sugiura N, Takahashi-Nakaguchi A, Gonoi T, Yokosuka O. Ultra-deep sequencing analysis of the hepatitis A virus 5'-untranslated region among cases of the same outbreak from a single source. Int J Med Sci 11(1): 60-64, 2014.
  39. Yagi K, Ishii M, Namkoong, H, Asami T, Fujiwara H, Nishimura T, Saito F, Kimizuka Y, Asakura T, Suzuki S, Kamo T, Tasaka S, Gonoi T, Kamei K, Betsuyaku T, Hasegawa N. Pulmonary nocardiosis caused by Nocardia cyriacigeorgica in patients with Mycobacterium avium complex lung disease: two case reports. BMC Infect Dis, 2014.
  40. Hagiwara D, Takahashi-Nakaguchi A, Toyotome T, Abe K, Yoshimi H, Kamei K, Gonoi T, Kawamoto S: NikA/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus. PLoS ONE 2;8(12):e80881, 2013.
  41. Oarada M, Miki T, Kohno S, Sakai, K, Nikawa T, Yoneyama M, Gonoi T: Refeeding with a standard diet after a 48-h fast elicits an inflammatory response in the mouse liver. J Nutr Biochem 24: 1314-1323, 2013.
  42. Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, Saito T, Okawa Y, Shibata N, Miyamoto T, Yamasaki S. Identification of distinct ligands for Mincle and Dectin-2 in the pathogenic fungus Malassezia. Cell Host Microbe 13(4): 477-488, 2013.
  43. Ferrari MDL, Resende MR, Sakai K, Muraosa Y, Lyra L, Gonoi T, Mikami Y, Tominaga K, Kamei K, Schreiber A, Trabasso P, Moretti ML. Visual analysis of DNA microarray data for accurate molecular identification of non-albicans Candida isolates from patients with candidemia episodes. J Clin Microbiol 51(11): 3826-3829, 2013.
  44. Tanaka N, Kusama T, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. Nagelamides X-Z, dimeric bromopyrrole alkaloids from a marine sponge Agelas sp. Org Lett 15(13): 3262-3265, 2013.
  45. Tanaka N, Asai M, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. Manzamenone O, new trimeric fatty acid derivative from a marine sponge Plakortis sp. Org Lett 15(10): 2518-1525, 2013.
  46. Kubota T, Kamijyo Y, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J. Zamamiphidin A, a new manzamine related alkaloid from an Okinawan marine sponge Amphimedon sp. Org Lett 15(3): 610-612, 2013.
  47. Kubota T, Ishiguro Y, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J. Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp. Bioorg Med Chem Lett 23(1): 244-247, 2013.
  48. Condas LA, Ribeiro MG, Yazawa K, de Vargas AP, Salerno T, Giuffrida R, Langoni H, Melville PA, Biesdorf S, Matsuzawa T, Gonoi T, Kastelic JP, Barkema HW. Molecular identification and antimicrobial susceptibility of Nocardia spp. isolated from bovine mastitis in Brazil. Vet Microbiol 167(3-4): 708-712, 2013.
  49. Tanaka N, Momose R, Takahashi Y, Kubota T, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp. Tetrahedron Lett 54 (31): 4038-4040, 2013.
  50. Tanaka N, Kusama T, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. Nagelamides U-W, bromopyrrole alkaloids from a marine sponge Agelas sp. Tetrahedron Lett 54 (29): 3794-3796, 2013.
  51. Yamaguchi H, Sekimoto E, Shirakami A, Shibata H, Ozaki S, Shigekiyo T, Noda T, Shikiji T, Kanda K, Hirose T, Matsuzawa T, Gonoi T: Testicular nocardiosis accompanied by cutaneous lesions in an immunocompetent man. Internal Med 52: 129-133, 2013.
  52. Wu S, Kanda T, Nakamoto S, Jiang X, Miyamura T, Nakatani SM, Ono SK, Takahashi-Nakaguchi A, Gonoi T, Yokosuka O: Prevalence of Hepatitis C Virus Subgenotypes 1a and 1b in Japanese Patients: Ultra-Deep Sequencing Analysis of HCV NS5B Genotype-Specific Region. PLoS ONE, 8 , art. no. e73615. 2013.
  53. Tamura T, Matsuzawa T, Oji S, et al.: A genome sequence-based approach to taxonomy of the genus Nocardia. Anton Leeuw Int J G 102: 481-491, 2012
  54. Takahashi Y, Tanaka N, Kubota T, et al.: Heteroaromatic alkaloids, nakijinamines, from a sponge Suberites sp. Tetrahedron 68: 8545-8550, 2012
  55. Oarada M, Tsuzuki T, Nikawa T, Kohno S, Hirasaka K and Gonoi T: Refeeding with a high-protein diet after a 48 h fast causes acute hepatocellular injury in mice. British J Nutr 107: 1435-1444, 2012
  56. Kubota T, Iwai T, Takahashi-Nakaguchi A, Fromont J, Gonoi T and Kobayashi J: Agelasines O-U, new diterpene alkaloids with a 9-N-methyladenine unit from a marine sponge Agelas sp. Tetrahedron 68: 9738-9744, 2012
  57. Kobayashi N, Sueoka-Aragane N, Naganobu N, et al.: Disseminated nocardiosis caused by Nocardia Concava with acute respiratory failure and central nervous system involvement treated with linezolid. Internal Med 51: 3281-3285, 2012
  58. de Farias MR, Werner J, Ribeiro MG, et al.: Uncommon mandibular osteomyelitis in a cat caused by Nocardia africana. BMC Veterinary Research 8, 2012
  59. Condas LAZ, Ribeiro MG, Gonoi T, et al.: Molecular identification and thermoresistance to boiling of Nocardia farcinica and Nocardia cyriacigeorgica from bovine bulk tank milk. Brazilian Journal of Microbiology 43: 1038-1041, 2012
  60. Tanaka N, Momose R, Shibazaki A, Gonoi T, Fromont J and Kobayashi J: Stelliferins J-N, isomalabaricane-type triterpenoids from Okinawan marine sponge Rhabdastrella cf. globostellata. Tetrahedron 67: 6689-6696, 2011
  61. Tanaka N, Mamemura T, Shibazaki A, Gonoi T and Kobayashi J: Yojironins E-I, prenylated acylphloroglucinols from Hypericum yojiroanum. Bioorganic and Medicinal Chemistry Letters 21: 5393-5397, 2011
  62. Takahashi Y, Kubota T, Shibazaki A, Gonoi T, Fromont J and Kobayashi J: Nakijinamines C-E, new heteroaromatic alkaloids from the sponge suberites species. Organic Lett 13: 3016-3019, 2011
  63. Shibazaki A, Tateno H, Akikazu A, Hirabayashi J and Gonoi T: Profiling the cell surface glycome of five fungi using lectin microarray. Journal of Carbohydrate Chemistry 30: 147-164, 2011
  64. Shibazaki A, Omoto Y, Kudo T, et al.: Streptomyces coacervatus sp. nov., isolated from the intestinal tract of Armadillidium vulgare. International Journal of Systematic and Evolutionary Microbiology 61: 1073-1077, 2011
  65. Oarada M, Tsuzuki T, Nikawa T, Kohno S, Hirasaka K and Gonoi T: Refeeding with a high-protein diet after a 48 h fast causes acute hepatocellular injury in mice. British Journal of Nutrition: 1-10, 2011
  66. Mamemura T, Tanaka N, Shibazaki A, Gonoi T and Kobayashi J: Yojironins A-D, meroterpenoids and prenylated acylphloroglucinols from Hypericum yojiroanum. Tetrahedron Lett 52: 3575-3578, 2011
  67. Imai K, Koibuchi T, Kikuchi T, et al.: Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient. Journal of Infection and Chemotherapy 17: 547-551, 2011
  68. Tanaka N, Otani M, Kashiwada Y, et al.: Petiolins J-M, prenylated acylphloroglucinols from Hypericum pseudopetiolatum var. kiusianum. Bioorganic and Medicinal Chemistry Letters 20: 4451-4455, 2010
  69. Takeda K, Kang Y, Yazawa K, Gonoi T and Mikami Y: Phylogenetic studies of Nocardia species based on gyrB gene analyses. Journal of Medical Microbiology 59: 165-171, 2010
  70. Oarada M, Igarashi M, Tsuzuki T, et al.: Effects of a high-protein diet on host resistance to paracoccidioides brasiliensis in mice. Bioscience, Biotechnology and Biochemistry 74: 620-626, 2010
  71. Kon Y, Kubota T, Shibazaki A, Gonoi T and Kobayashi J: Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp. Bioorganic and Medicinal Chemistry Letters 20: 4569-4572, 2010
  72. Kogure T, Shimada R, Ishikawa J, et al.: Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic. Antimicrobial Agents and Chemotherapy 54: 2385-2390, 2010
  73. Oarada M, Kamei K, Gonoi T, et al.: Beneficial effects of a low-protein diet on host resistance to Paracoccidioides brasiliensis in mice. Nutrition 25: 954-963, 2009
  74. Oarada M, Igarashi M, Tsuzuki T, et al.: Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice. Bioscience, Biotechnology and Biochemistry 73: 1994-1998, 2009
  75. Oarada M, Tsuzuki T, Gonoi T, et al.: Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice. Nutrition 24: 67-75, 2008
  76. Hanafy A, Kaocharoen S, Jover-Botella A, et al.: Multilocus microsatellite typing for Cryptococcus neoformans var. grubii. Medical Mycology 46: 685-696, 2008
  77. Dahlem YA, Horn TFW, Buntinas L, Gonoi T, Wolf G and Siemen D: The human mitochondrial KATP channel is modulated by calcium and nitric oxide: A patch-clamp approach. Biochimica et Biophysica Acta - Bioenergetics 1656: 46-56, 2004
  78. Miki T, Minami K, Zhang L, et al.: ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue. American Journal of Physiology - Endocrinology and Metabolism 283: E1178-E1184, 2002
  79. Sunaga Y, Gonoi T, Shibasaki T, et al.: The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: Comparison with the sulfonylureas and nateglinide. Europ J Pharmacol 431: 119-125, 2001
  80. Gonoi T, Béguin P, Nagashima K, Nishimura M and Seino S: PKA-mediated phosphorylation and functional modulation of the ATP-sensitive K+ channels. Kidney International 60: 404, 2001
  81. Béguin P, Nagashima K, Gonoi T, et al.: Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature 411: 701-706, 2001
  82. Kawaki J, Nagashima K, Tanaka J, et al.: Unresponsiveness to glibenclamide during chronic treatment induced by reduction of ATP-sensitive K+ channel activity. Diabetes 48: 2001-2006, 1999
  83. Béguin P, Nagashima K, Nishimura M, Gonoi T and Seino S: PKA-mediated phosphorylation of the human K(ATP) channel: Separate roles of Kir6.2 and SUR1 subunit phosphorylation. EMBO J 18: 4722-4732, 1999
  84. Sánchez JA, Gonoi T, Inagaki N, Katada T and Seino S: Modulation of reconstituted ATP-sensitive K+ channels by GTP-binding proteins in a mammalian cell line. J Physiol (Lond) 507: 315-324, 1998
  85. Miki T, Nagashima K, Tashiro F, et al.: Defective insulin secretion and enhanced insulin action in K(ATP) channel-deficient mice. Proc Natl Acad Sci USA 95: 10402-10406, 1998
  86. Suzuki M, Kotake K, Fujikura K, et al.: Kir6.1: A possible subunit of ATP-sensitive K+ channels in mitochondria. Biochemical and Biophysical Research Communications 241: 693-697, 1997
  87. Seino S, Inagaki N, Namba N, et al.: Molecular basis of functional diversity of ATP-sensitive K+ channels. Japanese Journal of Physiology 47: S3-S4, 1997
  88. Nestorowicz A, Inagaki N, Gonoi T, et al.: A nonsense mutation in the inward rectifier potassium channel gene, Kir6.2, is associated with familial hyperinsulinism. Diabetes 46: 1743-1748, 1997
  89. Misaka T, Kusakabe Y, Emori Y, Gonoi T, Arai S and Abe K: Taste buds have a cyclic nucleotide-activated channel, CNGgust. J Biol Chem 272: 22623-22629, 1997
  90. Miki T, Tashiro F, Iwanaga T, et al.: Abnormalities of pancreatic islets by targeted expression of a dominant- negative k(ATP) channel. Proc Natl Acad Sci USA 94: 11969-11973, 1997
  91. Inagaki N, Gonoi T and Seino S: Subunit stoichiometry of the pancreatic β-cell ATP-sensitive K+ channel. FEBS Lett 409: 232-236, 1997
  92. Seino S, Inagaki N, Namba N and Gonoi T: Molecular biology of the β-cell ATP-sensitive K+ channel. Diabetes Reviews 4: 177-190, 1996
  93. Namba N, Inagaki N, Gonoi T, Seino S and Seino Y: Kir2.2v: A possible negative regulator of the inwardly rectifying K+ channel Kir2.2. FEBS Letters 386: 211-214, 1996
  94. Inagaki N, Gonoi T, Clement Iv JP, et al.: A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Neuron 16: 1011-1017, 1996
  95. Inagaki N, Tsuura Y, Namba N, et al.: Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. J Biol Chem 270: 5691-5694, 1995
  96. Inagaki N, Kuromi H, Gonoi T, et al.: Expression and role of ionotropic glutamate receptors in pancreatic islet cells. FASEB J 9: 868-891, 1995
  97. Gonoi T, Inagaki N, , Clement Iv JP, et al.: Reconstitution of IKATP: An inward rectifier subunit plus the sulfonylurea receptor. Science 270: 1166-1170, 1995
  98. Ihara Y, Yamada Y, Fujii Y, et al.: Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic β-cells. Molecular Endocrinology 9: 121-130, 1995
  99. Inagaki N, Yoshida H, Mizuta M, et al.: Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin- secreting cells. Proc Natl Acad Sci USA 91: 2679-2683, 1994
  100. Gonoi T, Mizuno N, Inagaki N, et al.: Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6. J Biol Chem 269: 16989-16992, 1994
  101. Gonoi T: Patch-clamp study of developmental changes in voltage-dependent ion channels of mouse skeletal muscle fibers. Annals of the New York Academy of Sciences 707: 352-355, 1993
  102. Gonoi T and Hasegawa S: Postnatal induction and neural regulation of inward rectifiers in mouse skeletal muscle. Pflugers Archiv European Journal of Physiology 418: 601-607, 1991
  103. Gonoi T and Hasegawa S: Induction of inward rectifiers in mouse skeletal muscle fibres in culture. Pflugers Archiv European Journal of Physiology 419: 657-661, 1991
  104. Gonoi T, Hagihara Y, Kobayashi J, Nakamura H and Ohizumi Y: Geographutoxin-sensitive and insensitive sodium currents in mouse skeletal muscle developing in situ. J Physiol (Lond) 414: 159-177, 1989
  105. Gonoi T and Hasegawa S: Post-natal disappearance of transient calcium channels in mouse skeletal muscle: Effects of denervation and culture. J Physiol (Lond) 401: 617-637, 1988